A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID-19

Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Zhangzhidong Road No. 99, Wuhan, 430060, China.

Abstract

Currently, coronavirus disease 2019 (COVID-19) is a global pandemic disease with significant morbidity and mortality. Ozone may exert its antiviral actions and ozone therapy has been demonstrated therapeutically usefulness in influenza and novel viruses. In this letter, two severe cases with COVID-19 received ozone therapy were described. The results showed that ozone therapy may promote recovery of clinical condition and improvement of chest CT images, shorten the duration of viral shedding and length of hospital stay.

Keywords: Coronavirus < Virus classification; Reovirus < Virus classification; SARS coronavirus < Virus classification.

No therapeutics has been proven effective for treatment of COVID-19 [1,2].
China has explored important clinical trials on a host of possible effective treatment options including ozone therapy. We introduced our experience in treating two confirmed cases by ozone therapy — Major Autohemotherapy (MAH) [3].
After the written informed consent was obtained, MAH was given to patients once daily for 7 consecutive days. Each time, 100 ml of venous blood was collected and mixed with O3 gas at the 1:1 ratio of oxygen-ozone to blood volume, with the final concentration of oxygen-ozone being 20ug/ml study. The clinical study was approved by the Clinical Research Ethics Committee of Renmin Hospital of
Wuhan University (WDRY2020-K020).

 

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