Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study)

2020 Siguranța și eficacitatea terapiei cu ozon la pacienții COVID-19 ușor până la moderat: Un studiu randomizat de faza I / II (studiu SEOT).

Affiliations 

Affiliations

  • 1Training and Education Department, President of Ozone Forum of India, Mumbai, India.
  • 2Head of the Clinical Department, Director of Ozone Forum of India, Mumbai, India.
  • 3Trustee in Department of Ozone Therapy, Lokmanya Medical Research Centre, Pune, India. Electronic address: vgvaidya178@gmail.com.
  • 4Department of Oncology, Integrated Cancer Treatment and Research Centre, Wagholi, Pune, India.
  • 5Department of Ozone Therapy, Lokmanya Medical Research Centre, Pune, India.
  • 6Indian Academy for Scientific Writing and Research, Pune, India. Electronic address: director@iaswar.com.
  • 7Clinical Research, Department of Ozone Therapy, Lokmanya Medical Research Centre, Pune, India
  • PMID: 33421928      PMCID: PMC7758022     DOI: 10.1016/j.intimp.2020.107301

Abstract

Introduction: The Corona virus disease 19 (COVID-19) has accounted for multiple deaths and economic woes.While the entire medical fraternity and scientists are putting their best feet forward to find a solution to contain this deadly pandemic, there is a growing interest in integrating other known alternative therapies in to standard care. This study is aimed at evaluating the safety and efficacy of ozone therapy (OT), as an adjuvant to the standard of care (SOC).

Methods: In the current randomized control trial, 60 patients with mild to moderate score NEWS score were included in two parallel groups (n = 30/group). The interventional group (OZ) received ozonized rectal insufflation and minor auto haemotherapy, daily along with SOC, while the control group (ST) received SOC alone. The main outcome measures included changes in clinical features, oxygenation index (SpO2), NEWS score, Reverse transcription polymerase chain reaction(RT-PCR), inflammatory markers, requirement of advanced care, and metabolic profiles.

Results: The OZ group has shown clinically significant improvement in the mean values of all the parameters tested compared to ST Group. However, statistical significance were only observed in RT-PCR negative reaction (P = 0.01), changes in clinical symptoms (P < 0.05) and requirement for Intensive care (P < 0.05). No adverse events were reported in OZ group, as against 2 deaths reported in ST group.

Conclusion: OT when integrated with SOC can improve the clinical status and rapidly reduce the viral load compared to SOC alone, which facilitate early recovery and check the need for advanced care and mortality as demonstrated in this study.

Keywords: Anti-viral; COVID-19; Integrative medicine; Oxygen therapy; Ozone therapy; SARS-COV-2.

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