COVID19 and ozone therapy – protocol

by Dr. Jose Baeza-Noci1, Dr. Lamberto Re2, Dr. Silvia Menendez2

1 WFOT Vice-President; 2 WFOT Scientific Advisory Committee

INTRODUCTION.

SARS-Cov2 has a mean incubation period of 5 days, although it can reach up to 2 weeks’.
Infected patients evolve differently and extreme cases die after 10 days of being infected. Most patients ask for medical help after 5 days of suffering a catarrhal syndrome that worsens. They usually remain in-hospital for 3 weeks before discharge but according to age and concomitant pathology, 10% go to ICU. The prognosis there is also related with age and concomitant diseases as indicated by WHO.

 Ozone therapy possible role in COVID-19.

Bocci and cols. tested in vivo effects of ozone in patients with different infections and discovered the following facts:

1- Ozone improves lung and peripheral tissue oxygenation and gases exchange because of peripheral vase-dilatation mediated by nitrosotyols and enhanced glucolysis in erythrocytes that produce more ATP and secondary higher 2,3-DPG levels (Bohr effect) and more elasticity because an optimal functioning of Na/K+ membrane pump.

2- Ozone modulates the NRF2 and this produces two effects. First, normalize the redox balance through the increase in antioxidants in cytoplasma, mitochondria and finally, plasma, mainly glutatione peroxidase, but also glutatione reductase, NADPH and SOD. Second ,induces the production of HO-1, a protective enzyme, together heat-shock proteins like HSP60, HSP70 and HSP90. Third , activates the NFKbeta that modulates the production of proinflammatory interleukines in inflammated tissues. All three effects contribute to restore the normal functioning of the inflammated tissues and decrease the amount of plasma interleukines.

Many pre-clinical papers have confirmed these results, but there are also clinical studies that have confirmed these facts:
– Hernandez-Rosales and cols. in 2005 reported the improvement of asthma patients in both, analytical tests and respiratory function after ozone systemic treatment and also compare the effect of different doses of ozone.
– Borrelli and Bocci in 2014 confirmed these results in other group of chronic obstructive pulmonary disease (COPD) patients.
– Vinnik and cols. proved in 2015 the decrease in IL6 and other pro-inflammatorio citokynes in diabetes mellitus patients treated with systemic ozone.
– Delgado-Roche and cols. also published in 2017 the same findings in multiple sclerosis patients.
– Tong N and cols. published in 2018 a great decrease in IL6 in patients suffering lumbar disc herniation and treated with systemic ozone.
Many papers have been published about the improvement of bacterial infection by using systemic ozone. Bocci also proposed the rationale of this indication. Fortunately, we have several clinical studies about the efficacy of ozone in viral infections: herpes, hepatitis B, hepatitis C and HIV.

Ozone administration ways.

Ozone for systemic diseases should be used in a systemic way :

A. Indirect Endovenous Administration (IEV). As ozone is a gas cannot be directly injected into the blood mainstream, to avoid gas embolism. Special medical devices have been manufactured and EU certificated by different manufacturers to allow ozone dissolve into the patients’ blood risk free. For details on this technique, please read World Federation of Ozone Therapy – WFOT’s book . Based on the information from the three Chinese Hospitals that are presently performing and official clinical trial and also on the protocol presented and pre-accepted in Universitá della Sapienza in Rome, the proposed treatment will be:

– 100 mL of blood and 100 mL of ozone gas at 30 mcgr/mL concentration.
– In-hospital patients: each 12 hours application for minimum 14 days.

B. Rectal Inssuflation (RI). Rectal inssuflation is not so exact as IEV but it can be the only option for patients where peripheral veins don’t allow the previous technique. For details on this technique, please read World Federation of Ozone Therapy – WFOT’s book

We propose the following protocol: